Optimizing a Fatty Acid Synthase Inhibitor for Possible Application Toward Breast Cancer.

Item

Title

Optimizing a Fatty Acid Synthase Inhibitor for Possible Application Toward Breast Cancer.

Description

L. P. Young Student Center, West Dining and Flag Room

Breast cancer, among many other types of cancer, depends on a constant supply of fatty acids made by the enzyme Fatty Acid Synthase (FAS) for fuel, the formation of cell membranes, and for the formation of lipids that stimulate cell growth. FAS is therefore associated with clinically aggressive tumor behavior, tumor-cell growth and survival, and has become a target for chemotherapy development. A previously made molecule has proven to inhibit FAS and block the formation of fatty acids important for cancer cells, but is not stable in blood plasma. This project investigates changes to that compound hypothesized to maintain FAS inhibition while improving the stability of the compound in a living system. If successful, the new compound could be a useful lead to investigate the role of FAS inhibition in animal models of breast cancer. The design, synthesis, purification, and characterization of the new compounds will be presented.

Paul Baures

Contributor

Keene State College

Creator

Victoria A. Smolenski

Date

2016-04-09

Identifier

https://commons.keene.edu/s/KSCArchive/item/21049

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

Item sets

AEC 2016 School of Sciences and Social Sciences

Site pages

School of Sciences and Social Sciences