Improving the Activity of a Fatty Acid Synthase Inhibitor by Structural Mimicry

Item

Title

Improving the Activity of a Fatty Acid Synthase Inhibitor by Structural Mimicry

Description

David F. Putnam Science Center, Room 127

There are many types of cancer that depend on a constant supply of fatty acids made by an enzyme known as Fatty Acid Synthase (FAS). It has been proposed that preventing FAS from making fatty acids could be useful in the overall treatment of these cancers. The basis of this project is to mimic molecules used by FAS and thus trick the enzyme into decelerating the production of fatty acids, making it easier to kill cancer cells. Techniques learned in an organic chemistry class such as synthesis, chromatography, and spectroscopy are used to create, purify, and characterize these molecules. Once purified, the molecules are sent to the Norris Cotton Cancer Center to be tested for toxicity to cancer cells, as well as their stability in a living system. More molecules are continuously synthesized as the research progresses and demonstrate improved stability and activity.

Paul Baures

Contributor

Keene State College

Creator

Evan M. Dunkley

Date

2016-04-09

Identifier

https://commons.keene.edu/s/KSCArchive/item/21040

Language

en_US

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

Item sets

AEC 2016 School of Sciences and Social Sciences

Site pages

School of Sciences and Social Sciences