Understanding the differences in inflammatory and cytotoxicity effects from exposure to diesel and biodiesel particles in a human lung cell line

Item

Title

Understanding the differences in inflammatory and cytotoxicity effects from exposure to diesel and biodiesel particles in a human lung cell line

Description

David F. Putnam Science Center, Room 163

While biodiesel is widely perceived as a sustainable alternative to petroleum diesel fuel, there is limited information regarding the health implications from exposure to biodiesel and diesel particulate matter (PM) generated in 'real world' combustion operations. Exposure of diesel or biodiesel PM can trigger cell signaling pathways resulting in the release of proinflammatory proteins, in particular interleukin 8 (IL-8). Chronic pulmonary inflammation from PM exposure has been associated with health conditions such as chronic obstructive pulmonary disease (COPD) and cardiovascular disease. This study aims to assess the differences in IL-8 expression in a human epithelial cell line (BEAS-2B) when exposed to both diesel and biodiesel PM. We will also consider how PM exposure relates to increased cellular death (cytotoxicity). Gaining a better understanding of the impact of biodiesel PM exposure on human health is integral when considering its potential as an alternative fuel source.

Nora Traviss

Contributor

Keene State College

Creator

Audrey Boraski

Date

2016-04-09

Identifier

https://commons.keene.edu/s/KSCArchive/item/21036

Language

en_US

Subject

Environmental Studies

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

Item sets

AEC 2016 School of Sciences and Social Sciences

Site pages

School of Sciences and Social Sciences