Investigating the Metabolic Stability of Fatty Acid Synthase Inhibitors

Item

Title

Investigating the Metabolic Stability of Fatty Acid Synthase Inhibitors

Description

Recent research has indicated that inhibition of fatty acid synthase, a mammalian enzyme that catalyzes production of fatty acids, may slow the growth of cancerous tumors. The Baures laboratory at Keene State College has synthesized compounds with the potential to inhibit this enzyme, and investigated their metabolic stability. Metabolic stability influences a drug compound's ability to be physiologically active before it is decomposed. In vitro experiments were conducted to test the stability of the compounds in the presence of metabolic liver enzymes and digestive protease enzymes. The concentrations of compounds before and after the assays were compared to determine each compound's stability. Currently, in vitro experiments are being designed that will confirm the suspected mechanism of action of these compounds. Assuming these compounds inhibit fatty acid synthase as we expect, the compound with ideal metabolic stability may move forward as a potential drug candidate for tumor inhibition.
Paul Baures

Contributor

Keene State College

Creator

Emily Wollert

Date

2017-10-11

Identifier

http://hdl.handle.net/20.500.12088/8119

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

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