Selective Conformational Restriction of a Fatty Acid Synthase Inhibitor

Item

Title

Selective Conformational Restriction of a Fatty Acid Synthase Inhibitor

Description

Breast and other cancer cells greatly rely on the supply of fatty acids to grow and divide rapidly, and also to support energy needs. Healthy cells, on the other hand, generally get enough fatty acids from the diet to support their needs. Due to this, widespread efforts to generate molecules that inhibit the production of fatty acids have been made. This research project is an attempt to improve an identified inhibitor of fatty acid synthesis that can assume two different conformations, a property that varies the size and shape of the molecule. We hypothesize that only one of these conformations is biologically active; synthesizing one of them will determine which one will be useful against fighting the disease. Thus, this project is an effort to prepare a new molecule that mimics one specific conformation in its size and shape in an effort to gain potency and specificity of the new compound. The design and progress to date will be described.
Paul Baures

Contributor

Keene State College

Creator

Christina G. Connor
Margaret J. Maloy

Date

2017-10-11

Identifier

http://hdl.handle.net/20.500.12088/8095

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

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