Structural Optimization and In Vitro Analysis of a Fatty Acid Synthase Inhibitor

Item

Title

Structural Optimization and In Vitro Analysis of a Fatty Acid Synthase Inhibitor

Description

There are multiple types of cancer that depend on a constant supply of fatty acids made by an enzyme known as Fatty Acid Synthase (FAS). It has been proposed that preventing FAS from making fatty acids could be useful in the overall treatment of these cancers. The purpose of this project is to mimic molecules that are used by FAS and thus trick the enzyme into decelerating the production of fatty acids, helping to kill cancer cells. This project is a collaborative effort between Keene State College and the Norris Cotton Cancer Center in Lebanon, NH. The former creates the molecules through the application of techniques learned in an organic chemistry class, whereas the latter defines the molecules? anticancer properties by introducing the molecule to breast cancer cells. The presentation will cover results obtained in the past year from working on both sides of the project and our future plans.

Paul Baures

Contributor

Keene State College

Creator

Evan M. Dunkley

Date

2017-10-11

Identifier

http://hdl.handle.net/20.500.12088/8082

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

Item sets

AEC 2017 School of Sciences and Social Sciences

Site pages

School of Sciences and Social Sciences