Synthesis and Characterization of Potential Fatty Acid Synthase Inhibitors

Item

Title

Synthesis and Characterization of Potential Fatty Acid Synthase Inhibitors

Description

Fatty Acid synthase (FASN) is an enzyme that catalyzes the production of fatty acids. It has been observed that this enzyme is elevated in cancer cells, since fatty acids are required as both a fuel source and for the synthesis of cell membranes. Thus, inhibitors of fatty acid synthase are being researched in the treatment of breast and other cancers. A series of new compounds that are similar to a previously identified fatty acid synthase inhibitor are prepared in this project in order to determine how the structure influences the biological activity. The synthesis and characterization of the new compounds will be presented. It is expected that the biological activity of this series of compounds, which will be determined by collaborators, can help identify the structural features important for fatty acid synthase inhibition. This could then lead to improved compounds for testing the inhibition of this enzyme in cancer models.
Paul Baures

Contributor

Keene State College

Creator

James Shannon

Date

2015-04-11

Identifier

http://hdl.handle.net/20.500.12088/7603

Language

en_US

Subject

Chemistry

Type

Presentation

Rights

http://rightsstatements.org/vocab/InC/1.0/

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