Synthesis and Characterization of Potential Fatty Acid Synthase Inhibitors

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dc.contributor.author James Shannon
dc.date.accessioned 2018-01-23T20:22:07Z
dc.date.available 2018-01-23T20:22:07Z
dc.date.issued 04/11/2015
dc.identifier.uri http://hdl.handle.net/20.500.12088/7603
dc.description dc.description
dc.description.abstract Fatty Acid synthase (FASN) is an enzyme that catalyzes the production of fatty acids. It has been observed that this enzyme is elevated in cancer cells, since fatty acids are required as both a fuel source and for the synthesis of cell membranes. Thus, inhibitors of fatty acid synthase are being researched in the treatment of breast and other cancers. A series of new compounds that are similar to a previously identified fatty acid synthase inhibitor are prepared in this project in order to determine how the structure influences the biological activity. The synthesis and characterization of the new compounds will be presented. It is expected that the biological activity of this series of compounds, which will be determined by collaborators, can help identify the structural features important for fatty acid synthase inhibition. This could then lead to improved compounds for testing the inhibition of this enzyme in cancer models.
dc.description.sponsorship Paul Baures
dc.language.iso en_US
dc.publisher Keene State College
dc.subject Chemistry
dc.title Synthesis and Characterization of Potential Fatty Acid Synthase Inhibitors
dc.type Presentation

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