Presentation Title

Understanding the differences in inflammatory and cytotoxicity effects from exposure to diesel and biodiesel particles in a human lung cell line

Presenter Information

audrey boraskiFollow

Presentation Type

Oral Presentation

School

School of Sciences and Social Sciences

Discipline

Environmental Studies

Mentor

Nora Traviss

Date & Time

April 9th at 2 PM - 3 PM

Location

David F. Putnam Science Center, Room 163

Abstract

While biodiesel is widely perceived as a sustainable alternative to petroleum diesel fuel, there is limited information regarding the health implications from exposure to biodiesel and diesel particulate matter (PM) generated in 'real world' combustion operations. Exposure of diesel or biodiesel PM can trigger cell signaling pathways resulting in the release of proinflammatory proteins, in particular interleukin 8 (IL-8). Chronic pulmonary inflammation from PM exposure has been associated with health conditions such as chronic obstructive pulmonary disease (COPD) and cardiovascular disease. This study aims to assess the differences in IL-8 expression in a human epithelial cell line (BEAS-2B) when exposed to both diesel and biodiesel PM. We will also consider how PM exposure relates to increased cellular death (cytotoxicity). Gaining a better understanding of the impact of biodiesel PM exposure on human health is integral when considering its potential as an alternative fuel source.

Grant Funded

1

Type of Grant

Faculty Grant

Grant Name

National Institute of Health

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Apr 9th, 2:00 PM

Understanding the differences in inflammatory and cytotoxicity effects from exposure to diesel and biodiesel particles in a human lung cell line

David F. Putnam Science Center, Room 163

While biodiesel is widely perceived as a sustainable alternative to petroleum diesel fuel, there is limited information regarding the health implications from exposure to biodiesel and diesel particulate matter (PM) generated in 'real world' combustion operations. Exposure of diesel or biodiesel PM can trigger cell signaling pathways resulting in the release of proinflammatory proteins, in particular interleukin 8 (IL-8). Chronic pulmonary inflammation from PM exposure has been associated with health conditions such as chronic obstructive pulmonary disease (COPD) and cardiovascular disease. This study aims to assess the differences in IL-8 expression in a human epithelial cell line (BEAS-2B) when exposed to both diesel and biodiesel PM. We will also consider how PM exposure relates to increased cellular death (cytotoxicity). Gaining a better understanding of the impact of biodiesel PM exposure on human health is integral when considering its potential as an alternative fuel source.