Presentation Title

Optimization of Reaction Conditions for the Synthesis of Thiosemicarbazones using a Microwave Reactor

Presentation Type

Poster

School

School of Sciences and Social Sciences

Discipline

Chemistry

Mentor

Brian Anderson

Abstract

Previously, our research group has focused on making a class of molecules called thiosemicarbazones using a traditional synthesis method which takes up to a week to complete. A new route to synthesize these molecules was discovered using a microwave reactor which can complete a reaction in as little as 10 minutes. Just as a microwave can be used in the home to heat up water more quickly, a microwave can be used in the laboratory to facilitate reactions more quickly. The goal of this project is to determine the optimal reaction conditions such as choice of solvent and microwave settings to create the most amount of product in a minimal amount of time. The reaction progress will be monitored using a liquid chromatography instrument. After optimization, the developed method can be expanded to produce a variety of similar molecules in an effort to build a library of thiosemicarbazones.

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Optimization of Reaction Conditions for the Synthesis of Thiosemicarbazones using a Microwave Reactor

Previously, our research group has focused on making a class of molecules called thiosemicarbazones using a traditional synthesis method which takes up to a week to complete. A new route to synthesize these molecules was discovered using a microwave reactor which can complete a reaction in as little as 10 minutes. Just as a microwave can be used in the home to heat up water more quickly, a microwave can be used in the laboratory to facilitate reactions more quickly. The goal of this project is to determine the optimal reaction conditions such as choice of solvent and microwave settings to create the most amount of product in a minimal amount of time. The reaction progress will be monitored using a liquid chromatography instrument. After optimization, the developed method can be expanded to produce a variety of similar molecules in an effort to build a library of thiosemicarbazones.