Presentation Title

Selective Conformational Restriction of a Fatty Acid Synthase Inhibitor

Presentation Type

Poster

School

School of Sciences and Social Sciences

Discipline

Chemistry

Mentor

Paul Baures

Abstract

Breast and other cancer cells greatly rely on the supply of fatty acids to grow and divide rapidly, and also to support energy needs. Healthy cells, on the other hand, generally get enough fatty acids from the diet to support their needs. Due to this, widespread efforts to generate molecules that inhibit the production of fatty acids have been made. This research project is an attempt to improve an identified inhibitor of fatty acid synthesis that can assume two different conformations, a property that varies the size and shape of the molecule. We hypothesize that only one of these conformations is biologically active; synthesizing one of them will determine which one will be useful against fighting the disease. Thus, this project is an effort to prepare a new molecule that mimics one specific conformation in its size and shape in an effort to gain potency and specificity of the new compound. The design and progress to date will be described.

Grant Funded

1

Type of Grant

Faculty Grant

Grant Name

Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number P20GM103506

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Selective Conformational Restriction of a Fatty Acid Synthase Inhibitor

Breast and other cancer cells greatly rely on the supply of fatty acids to grow and divide rapidly, and also to support energy needs. Healthy cells, on the other hand, generally get enough fatty acids from the diet to support their needs. Due to this, widespread efforts to generate molecules that inhibit the production of fatty acids have been made. This research project is an attempt to improve an identified inhibitor of fatty acid synthesis that can assume two different conformations, a property that varies the size and shape of the molecule. We hypothesize that only one of these conformations is biologically active; synthesizing one of them will determine which one will be useful against fighting the disease. Thus, this project is an effort to prepare a new molecule that mimics one specific conformation in its size and shape in an effort to gain potency and specificity of the new compound. The design and progress to date will be described.