Presentation Title

Investigating the Metabolic Stability of Fatty Acid Synthase Inhibitors

Presentation Type

Poster

School

School of Sciences and Social Sciences

Discipline

Chemistry

Mentor

Paul Baures

Abstract

Recent research has indicated that inhibition of fatty acid synthase, a mammalian enzyme that catalyzes production of fatty acids, may slow the growth of cancerous tumors. The Baures laboratory at Keene State College has synthesized compounds with the potential to inhibit this enzyme, and investigated their metabolic stability. Metabolic stability influences a drug compound’s ability to be physiologically active before it is decomposed. In vitro experiments were conducted to test the stability of the compounds in the presence of metabolic liver enzymes and digestive protease enzymes. The concentrations of compounds before and after the assays were compared to determine each compound’s stability. Currently, in vitro experiments are being designed that will confirm the suspected mechanism of action of these compounds. Assuming these compounds inhibit fatty acid synthase as we expect, the compound with ideal metabolic stability may move forward as a potential drug candidate for tumor inhibition.

Grant Funded

1

Type of Grant

Faculty Grant

Grant Name

NIH Grant No. P20GM103506 (NH-INBRE)

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Investigating the Metabolic Stability of Fatty Acid Synthase Inhibitors

Recent research has indicated that inhibition of fatty acid synthase, a mammalian enzyme that catalyzes production of fatty acids, may slow the growth of cancerous tumors. The Baures laboratory at Keene State College has synthesized compounds with the potential to inhibit this enzyme, and investigated their metabolic stability. Metabolic stability influences a drug compound’s ability to be physiologically active before it is decomposed. In vitro experiments were conducted to test the stability of the compounds in the presence of metabolic liver enzymes and digestive protease enzymes. The concentrations of compounds before and after the assays were compared to determine each compound’s stability. Currently, in vitro experiments are being designed that will confirm the suspected mechanism of action of these compounds. Assuming these compounds inhibit fatty acid synthase as we expect, the compound with ideal metabolic stability may move forward as a potential drug candidate for tumor inhibition.