Presentation Title

Organometallic Synthesis Of Novel Thiosemicarbazone Ligands And Metal Complexes And Structural Analysis By X-Ray Diffraction

Presenter Information

Sean Millikan

Mentor

Brian Anderson and Jerry Jasinski

Location

L. P. Young Student Center – Lantern And East Dining Rooms

Abstract

Thiosemicarbazones are an interesting class of metal binding compounds. They have been shown to display biological activity including anti-parasitic, anti-bacterial and anti-tumoral properties. Further, both the unbound compound and their metal complexes have shown anti-tumor activity, however the metal complex was found to have enhanced pharmacological activity. The properties of these compounds can be differentiated by adding and changing substituents on the ring that contain varying electronic effects. A variety of novel thiosemicarbazones compounds have been developed and reacted with palladium or platinum complexes to make their corresponding productions. The goals are to synthesize and structurally characterize the ligands and metal complexes using X-Ray Diffraction which is an effective method for determining molecular structures of crystalized compounds. Eventually the library of complexes will be investigated to see the effect changes in structure have on their biological activity.

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Apr 11th, 4:15 PM Apr 11th, 5:15 PM

Organometallic Synthesis Of Novel Thiosemicarbazone Ligands And Metal Complexes And Structural Analysis By X-Ray Diffraction

L. P. Young Student Center – Lantern And East Dining Rooms

Thiosemicarbazones are an interesting class of metal binding compounds. They have been shown to display biological activity including anti-parasitic, anti-bacterial and anti-tumoral properties. Further, both the unbound compound and their metal complexes have shown anti-tumor activity, however the metal complex was found to have enhanced pharmacological activity. The properties of these compounds can be differentiated by adding and changing substituents on the ring that contain varying electronic effects. A variety of novel thiosemicarbazones compounds have been developed and reacted with palladium or platinum complexes to make their corresponding productions. The goals are to synthesize and structurally characterize the ligands and metal complexes using X-Ray Diffraction which is an effective method for determining molecular structures of crystalized compounds. Eventually the library of complexes will be investigated to see the effect changes in structure have on their biological activity.