Presentation Title

An investigation of Thiosemicarbazone Ligands in “Green” Palladium Cross-coupling

Presenter Information

Jeffrey Hall

Mentor

Brian Anderson

Location

David F. Putnam Science Center - 161

Abstract

Organometallic catalysts are a diverse class of molecules utilized in the manufacture of natural products, pharmaceuticals, and other specialty chemicals. As further efforts are made to understand catalytic mechanisms and abilities, a broader range of viable and economical alternatives to existing production methods can be established. Currently, there is a need to design new complexes that can function selectively and under “green”, or environmentally sustainable conditions, such as avoiding excess solvent and energy usage or reducing chemical waste. This research reports the synthesis and characterization of novel thiosemicarbazone ligands and their associated palladium(II) complexes. An examination of the catalytic activity of these compounds, under mild conditions (lower temperatures) with aqueous solvents (reduced hazardous waste), has shown them to be effective in cross-coupling reactions. The formation of new carbon-carbon(C-C) bonds through cross-coupling has simplified existing synthetic routes and made an extensive category of new chemical compounds possible to produce.

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Apr 11th, 1:55 PM Apr 11th, 2:55 PM

An investigation of Thiosemicarbazone Ligands in “Green” Palladium Cross-coupling

David F. Putnam Science Center - 161

Organometallic catalysts are a diverse class of molecules utilized in the manufacture of natural products, pharmaceuticals, and other specialty chemicals. As further efforts are made to understand catalytic mechanisms and abilities, a broader range of viable and economical alternatives to existing production methods can be established. Currently, there is a need to design new complexes that can function selectively and under “green”, or environmentally sustainable conditions, such as avoiding excess solvent and energy usage or reducing chemical waste. This research reports the synthesis and characterization of novel thiosemicarbazone ligands and their associated palladium(II) complexes. An examination of the catalytic activity of these compounds, under mild conditions (lower temperatures) with aqueous solvents (reduced hazardous waste), has shown them to be effective in cross-coupling reactions. The formation of new carbon-carbon(C-C) bonds through cross-coupling has simplified existing synthetic routes and made an extensive category of new chemical compounds possible to produce.